anti-GPC3-CAR-T lymphocytes TAK-102

{
  "id": "MLC-T-ONC-010716",
  "term": "anti-GPC3-CAR-T lymphocytes TAK-102",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-CAR-T lymphocytes TAK-102 specifically targets and binds to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation.",
  "synonyms": [
    "CAR T cells TAK-102",
    "anti-GPC3 CAR T cells TAK-102",
    "glypican-3-specific CAR T cells TAK-102"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-gpc3-car-t-lymphocytes-tak-102/"
}