GPC3-targeted plasmid DNA vaccine NWRD06

{
  "id": "MLC-T-ONC-014023",
  "term": "GPC3-targeted plasmid DNA vaccine NWRD06",
  "field": "Oncology and biomedicine",
  "definition": "A plasmid DNA therapeutic cancer vaccine encoding glypican-3 (GPC3), with potential immunomodulating and antineoplastic activities. Upon intramuscular administration of GPC3-targeted plasmid DNA vaccine NWRD06 and following electroporation, the plasmids enter the cells, and the cells express GPC3 and elicit a GPC3-specific cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing GPC3. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gpc3-targeted-plasmid-dna-vaccine-nwrd06/"
}