IRDye800CW-labeled GPC3-targeted agent

{
  "id": "MLC-T-ONC-014568",
  "term": "IRDye800CW-labeled GPC3-targeted agent",
  "field": "Oncology and biomedicine",
  "definition": "A fluorescence imaging agent and an immunoconjugate comprised of a glypican 3 (GPC3)-targeting moiety conjugated to the near-infrared (NIR) fluorescent dye IRDye800CW, that can potentially be used for the imaging of GPC3-expressing tumor cells. Upon administration of the IRDye800CW-labeled GPC3-targeted agent, the GPC3-targeting moiety targets and binds to GPC3 expressed on tumor cells. Upon fluorescence imaging of the fluorophore IRDye800CW, the GPC3-expressing tumor cells can be visualized and detected. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation.",
  "synonyms": [
    "anti-GPC3-IRDye800CW",
    "anti-glypican-3-IRDye800CW"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/irdye800cw-labeled-gpc3-targeted-agent/"
}