IRDye800CW-nimotuzumab

{
  "id": "MLC-T-ONC-014570",
  "term": "IRDye800CW-nimotuzumab",
  "field": "Oncology and biomedicine",
  "definition": "A fluorescence imaging and contrast agent and immunoconjugate comprised of nimotuzumab, a humanized monoclonal antibody directed against the epidermal growth factor receptor (EGFR), conjugated to the near-infrared (NIR) fluorescent dye IRDye 800CW, with potential imaging use. Upon administration of IRDye800CW-nimotuzumab, the nimotuzumab moiety targets and binds to the extracellular domain of EGFR. Upon binding, IRDye 800 may be detected using NIR imaging, which facilitates the visualization and detection of EGFR-expressing tumor cells. EGFR is a receptor tyrosine kinase that may be overexpressed on the cell surfaces of various tumor types.",
  "synonyms": [
    "IRDye800CW-labeled nimotuzumab",
    "nimotuzumab-IRDye800CW"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/irdye800cw-nimotuzumab/"
}