Oncology and biomedicine terminology · MLC-0111
Oncology and biomedicine terms: I (790)
- I 131 monoclonal antibody CC49A radioimmunoconjugate of the humanized monoclonal antibody CC49 labeled with iodine I 131. Iodine I 131...
- I 131 monoclonal sntibody F19A radioimmunoconjugate of a murine monoclonal antibody (MoAb) F19 labelled with Iodine 131 (I-131). MoAb F19...
- IadademstatAn orally available inhibitor of lysine specific histone demethylase 1 (KDM1A; LSD1), with potential...
- IanalumabA fully human combinatorial antibody library (HuCAL)-derived monoclonal antibody targeting the...
- IAP antagonist TQB3728An orally bioavailable, second mitochondria-derived activator of caspases (SMAC)-mimetic and an antagonist of...
- IAP inhibitor APG-1387A small molecule, second mitochondria-derived activator of caspases (SMAC)-mimetic targeting inhibitor of...
- IAP inhibitor HGS1029The hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins...
- iAPA-based dendritic cells/cytotoxic T lymphocytesA cell-based product composed of dendritic cells (DCs) pulsed with tumor-associated antigens (TAAs) and...
- IbandronateA drug that is used to prevent and treat osteoporosis, and is being studied in the treatment of cancer that...
- Ibandronate sodiumThe sodium salt of ibadronic acid, a synthetic nitrogen-containing bisphosphonate. Ibandronic acid inhibits...
- IbcasertibAn orally available, small molecule inhibitor of select serine-threonine kinases, including aurora kinase B...
- IberdomideA modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with...
- Iberdomide hydrochlorideThe hydrochloride salt form of iberdomide, a modulator of the E3 ubiquitin ligase complex containing cereblon...
- IBMFSInherited bone marrow failure syndrome. A rare disorder in which a person’s bone marrow is unable to make...
- IbranceA drug used to treat women and men with certain types of hormone-receptor positive, HER2-negative breast...
- IbrexafungerpAn intravenous and orally bioavailable semisynthetic derivative of enfumafungin with potential antifungal...
- Ibritumomab tiuxetanA drug used to treat adults with certain types of B-cell non-Hodgkin lymphoma. It is also being studied in...
- IbrutinibA drug used alone or with other drugs to treat adults with chronic lymphocytic leukemia, small lymphocytic...
- IBSA disorder of the intestines commonly marked by abdominal pain, bloating, and changes in a person’s bowel...
- IbudilastAn orally bioavailable inhibitor of cyclic nucleotide phosphodiesterase (PDE), mainly PDE-3, -4, -10, and...
- IbuprofenA drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that...
- Ibuprofen injectionA formulation for intravenous injection containing ibuprofen, a propionic acid derivate and nonsteroidal...
- iC9-GD2-CAR-CD28-OX40-expressing autologous NKT cellsA preparation of autologous interleukin-15 (IL-15)-expressing natural killer T cells (NKT) transduced with a...
- iC9-GD2-CD28-OX40-expressing T lymphocytesModified T-lymphocytes expressing a 3rd generation chimeric antigen receptor (CAR) specific for the...
- IcatibantAn antagonist of the human bradykinin B2 receptor (B2R), that can be used for the treatment of hereditary...
- ICDA small device used to correct a heartbeat that is abnormal (too fast, too slow, or irregular). The device is...
- ICEAn abbreviation for a chemotherapy combination that is used to treat non-Hodgkin and Hodgkin lymphomas that...
- ICE regimenAn abbreviation for a chemotherapy combination that is used to treat non-Hodgkin and Hodgkin lymphomas that...
- ICI 182780A drug used to treat certain types of breast cancer. It is used alone or with ribociclib succinate in...
- ICI D1694An anticancer drug that stops tumor cells from growing by blocking the ability of cells to make DNA. It...
- IclusigA drug used alone or with other drugs to treat adults with certain types of chronic myelogenous leukemia or...
- Icodextrin solutionAn isosmotic solution containing icodextrin, a starch-derived, water-soluble glucose polymer, used in...
- IcosapentThe free fatty acid (FFA) form of eicosapentaenoic acid (EPA), a polyunsaturated long-chain fatty acid found...
- Icotinib hydrochlorideThe hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of epidermal growth...
- IcrucumabA fully human IgG1 monoclonal antibody directed against human vascular endothelial growth factor receptor 1...
- Idamycin PFSA drug used with other drugs to treat adults with acute myeloid leukemia. It is also being studied in the...
- Idarubicin hydrochlorideA drug used with other drugs to treat adults with acute myeloid leukemia. It is also being studied in the...
- Idarubicin-eluting beadsA sustained-release drug delivery embolization system containing small polymeric beads impregnated with the...
- IdasanutlinAn orally available, small molecule, antagonist of MDM2 (mouse double minute 2; Mdm2 p53 binding protein...
- IDC-PA type of cancer that usually begins in the glandular (secretory) tissue that lines the prostate and spreads...
- Idecabtagene vicleucelA treatment used for adults with multiple myeloma that came back or did not get better after treatment with...
- IDEC-Y2B8A drug used with the drug rituximab to treat certain types of B-cell non-Hodgkin lymphoma. It is also being...
- IdelalisibA drug used with rituximab to treat chronic lymphocytic leukemia that has come back. It is also being studied...
- IDH1 geneA gene that makes a protein that helps break down fats for energy and protect cells from harmful molecules...
- IDH1 inhibitor KY100001An orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1; IDH-1; IDH1 [NADP+] soluble) mutant...
- IDH1 inhibitor TQB3454An orally bioavailable, small molecule inhibitor of isocitrate dehydrogenase type 1 (IDH1; IDH-1; IDH1...
- IDH1(R132) inhibitor IDH305An inhibitor of the citric acid cycle enzyme isocitrate dehydrogenase [NADP] cytoplasmic (isocitrate...
- IDH1R132H mutation-targeting IDH1 peptide vaccineA peptide vaccine consisting of a 20-mer peptide derived from isocitrate dehydrogenase type 1 (IDH1)...
- IDH1R132H-specific peptide vaccine PEPIDH1MA peptide vaccine consisting of a peptide derived from isocitrate dehydrogenase 1 (IDH1) containing the point...
- IDH2 geneA gene that makes a protein that is found inside small structures in cells called mitochondria and that helps...
- IDH2 mutant inhibitor SH1573An orally bioavailable inhibitor of mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2; IDH-2) R140Q...
- IDH2 mutant inhibitor TQB3455An orally bioavailable inhibitor of mutated mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2...
- IdhifaA drug used to treat adults with acute myeloid leukemia that has come back or has not gotten better with...
- IdiopathicDescribes a disease of unknown cause.
- Idiopathic myelofibrosisA progressive, chronic disease in which the bone marrow is replaced by fibrous tissue and blood is made in...
- Idiopathic pneumonia syndromeA set of pneumonia-like symptoms (such as fever, chills, coughing, and breathing problems) that occur with no...
- Idiopathic pulmonary fibrosisA disease in which the alveoli (tiny air sacs at the end of the bronchioles in the lungs) are overgrown with...
- Idiopathic thrombocytopenic purpuraA condition in which platelets (blood cells that cause blood clots to form) are destroyed by the immune...
- Idiotype-pulsed autologous dendritic cell vaccine APC8020A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with tumor-derived clonal...
- IDO peptide vaccine IO102A second-generation peptide vaccine derived from the immunomodulatory enzyme indoleamine 2,3-dioxygenase...
- IDO1 inhibitorAny agent that inhibits the activity of the enzyme indoleamine 2,3-dioxygenase 1 (IDO1; IDO).
- IDO1 inhibitor KHK2455An orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential immunomodulating and...
- IDO-1 inhibitor LY3381916An orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1; IDO-1), with potential immunomodulating...
- IDO-1 inhibitor PF-06840003An orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential...
- IDO1 inhibitor RiMO-401An inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1; IDO-1), with potential immunomodulating and...
- IDO1/TDO2 inhibitor DN1406131An inhibitor of both the enzymes indoleamine 2,3-dioxygenase 1 (IDO1; IDO-1) and tryptophan 2,3-dioxygenase 2...
- IDO1/TDO2 inhibitor M4112An inhibitor of both the enzymes indoleamine 2,3-dioxygenase 1 (IDO1; IDO-1) and tryptophan 2,3-dioxygenase 2...
- IDO/TDO inhibitor HTI-1090An orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1; IDO-1) and the kynurenine-producing...
- IDO/TDO inhibitor LY-01013An orally bioavailable, small-molecule inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1; IDO-1) and the...
- IdoxifeneA drug that blocks the effects of estrogen.
- IdoxuridineA drug that reduces the risk of cancer cell growth by interfering with the cells' DNA.
- IDRFA term used in the staging of neuroblastoma. It describes certain features of the tumor found on an imaging...
- IdronoxilA synthetic flavonoid derivative. Idronoxil activates the mitochondrial caspase system, inhibits X-linked...
- Idronoxil suppository NOX66A proprietary, suppository-based formulation composed of idronoxil, a synthetic flavonoid derivative...
- Idroxioleic acidAn orally bioavailable, synthetic analog of the fatty acid oleic acid, with potential antitumor activity...
- Iduronicrin genleukocel-TA preparation of autologous plasmablasts genetically engineered to express alpha-L-iduronidase (IDUA...
- IENA term used to describe the presence of abnormal cells on the surface of or in the tissue that lines an...
- IEPAn education plan for children with certain disabilities or health conditions, such as cancer. By law, these...
- IFAA mixture of oil and water that is combined with a specific antigen to boost the immune response to that...
- IfebemtinibAn orally bioavailable inhibitor of the non-receptor, cytoplasmic tyrosine kinase protein tyrosine kinase 2...
- Ifetroban sodiumThe sodium salt form of ifetroban, an orally bioavailable thromboxane (TxA2) and prostaglandin H2 (PGH2) (TP)...
- IfexA drug used with other drugs to treat malignant testicular germ cell tumors that have already been treated...
- Ifinatamab deruxtecanAn antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody against the immunoregulatory...
- IFN alpha-2BA drug used alone or with other drugs to treat adults with AIDS-related Kaposi sarcoma, hairy cell leukemia...
- iFOBTA test that checks for occult (hidden) blood in the stool. A small sample of stool is placed in a special...
- IfosfamideA drug used with other drugs to treat malignant testicular germ cell tumors that have already been treated...
- Ifupinostat hydrochlorideThe hydrochloride salt form of ifupinostat,, an inhibitor of both phosphoinositide 3-kinase (PI3K) and...
- IgA protein that is made by B cells and plasma cells (types of white blood cells) and helps the body fight...
- IGFA protein made by the body that stimulates the growth of many types of cells. IGF is similar to insulin (a...
- IGF-1R antagonist BMS-754807An oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor...
- IGF-1R antisense oligodeoxynucleotide-treated autologous glioma cells IGV-001A preparation of irradiated autologous glioma cells treated ex vivo with IMV-001, an antisense...
- IGF-1R inhibitor OSI-906A substance being studied in the treatment of cancer. It blocks a protein called IGF-1R, which is found at...
- IGF-1R inhibitor PL225BAn orally bioavailable inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential...
- IGF-1R/IR inhibitor KW-2450An orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR)...
- IGF-methotrexate conjugateA conjugate containing the antimetabolite and antifolate agent methotrexate conjugated to insulin-like growth...
- IGFRA protein found on the surface of some types of cells that binds to insulin-like growth factor (IGF). This...
- IgG-RFT5-dgAA monoclonal antibody linked to a toxic substance. It is being studied in the treatment of melanoma that has...
- IgM-enriched immunoglobulinsAn immunoglobulin preparation consisting of immunoglobulin G (IgG) and immunoglobulin A (IgA), supplemented...
- IGRTA procedure that uses a computer to create a picture of a tumor to help guide the radiation beam during...
- IH636 grape seed extractA substance being studied for its ability to prevent damage to normal tissue caused by radiation therapy. It...
- IH636 grape seed proanthocyanidin extractAn oligomeric proanthocyanidin extracted from grape seeds. IH636 grape seed proanthocyanidin extract exhibits...
- IKKb-matured RNA-loaded autologous dendritic cells DCIKKbA cancer vaccine consisting of autologous, monocyte-derived dendritic cells (DCs) that are matured with tumor...
- IKZF1/IKZF3 protein degrader GLB-002An orally bioavailable protein degrader of the transcription factors Ikaros (Ikaros family zinc finger...
- IKZF2 protein degrader DKY709A low molecular weight (MW) degrader of the protein IKZF2 (Helios), with potential immunomodulating and...
- ILOne of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. ILs...
- IL-1One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-1...
- IL-10One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-10...
- IL-10 immunomodulator MK-1966An agent that downregulates the activity of the anti-inflammatory cytokine human interleukin-10 (IL-10), with...
- IL-10-armed anti-CD19 CAR-T cells Meta10-19A preparation of T lymphocytes that have been genetically modified to express a chimeric antigen receptor...
- IL-11One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-11...
- IL-12One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-12...
- IL-12/Anti-CTLA-4 monoclonal antibody-expressing oncolytic viral vector TG6050A genetically engineered oncolytic vaccinia viral (VV) vector expressing the human immunostimulating cytokine...
- IL-12-expressing exosome CDK-003Exosome engineered to display the human pro-inflammatory cytokine interleukin-12 (IL-12) in a fully active...
- IL-12-expressing HSV-1 NSC 733972A genetically engineered, replication selective, infected cell protein (ICP) 34.5 gene-deleted, oncolytic...
- IL-12-expressing mesenchymal stem cell vaccine GX-051Human mesenchymal stem cells (MSCs) transduced with a retroviral vector encoding a modified form of the...
- IL-12-Fc fusion protein KGX101An engineered fusion protein composed of the human pro-inflammatory cytokine interleukin-12 (IL-12) fused to...
- IL-12sc, IL-15sushi, IFNa and GM-CSF mRNA-based immunotherapeutic agent SAR441000An immunotherapeutic agent utilizing mRNA to encode the cytokines interleukin-12sc (IL-12sc)...
- IL-13One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-13...
- IL13Ralpha2-specific hinge-optimized 41BB-co-stimulatory CAR truncated CD19-expressing autologous T-lymphocytesA preparation of ex vivo expanded, genetically modified autologous central memory-enriched T-cells (Tcm)...
- IL13Ralpha2-specific hinge-optimized 4-1BB-co-stimulatory CAR/Truncated CD19-expressing autologous TN/MEM CellsA preparation of ex vivo expanded, genetically modified autologous naïve and memory T cells (TN/MEM)...
- IL-15 superagonist SOT201A cis-acting immunocytokine and human Fc fusion protein composed of a humanized, Fc-silenced monoclonal...
- IL-15/IL-15 receptor alpha heterodimer NIZ985A soluble, recombinant human heterodimer composed of the cytokine interleukin (IL)-15 and the IL-15 receptor...
- IL-15(N72D)/IL-15Ralpha-sFc fusion protein complex FL115A long-acting form of the cytokine interleukin (IL)-15 and a fusion protein complex composed of a mutated...
- IL-1-alfaOne of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- IL-1-alphaOne of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- IL-1BOne of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-1B...
- IL-1-betaOne of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- IL-2One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-2...
- IL-2 fusion protein PTX-912A fusion protein consisting of the cytokine interleukin-2 (IL-2) fused to an as of yet not fully elucidated...
- IL-2 mutein/Fc fusion protein HM16390A recombinant fusion protein and long-acting analog of the human cytokine interleukin 2 (IL-2; IL2)...
- IL-2 plasmid DNA/lipid complexAn immunotherapeutic agent consisting of a plasmid DNA encoding human Interleukin-2 (IL-2) complexed with a...
- IL-2 recombinant fusion protein ALT-801A recombinant protein consisting of the cytokine interleukin-2 (IL-2) fused to a humanized soluble T-cell...
- IL-2/9/15 gamma chain receptor inhibitor BNZ-1A pegylated peptide antagonist that binds to the common gamma chain (gc; IL2RG; CD132) of the signaling...
- IL-2/anti-IL-2 antibody conjugate SLC-3010A noncovalent conjugate consisting of the cytokine interleukin-2 (IL-2; IL2) and TCB2, a humanized antibody...
- IL-2/IL-12-based fusion protein CLN-617A single-chain fusion protein composed of the human cytokine interleukin-2 (IL-2), the collagen-binding...
- IL-2/Lptn gene-modified allogeneic neuroblastoma tumor cell vaccineA cancer vaccine consisting of allogeneic neuroblastoma tumor cells have been genetically modified to secrete...
- IL-3One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-3...
- IL-34 inhibitorAny inhibitor that targets and inhibits the cytokine interleukin-34 (IL-34).
- IL-4One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-4...
- IL-5One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-5...
- IL-6One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-6...
- IL-7One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-7...
- IlaprazoleA substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. A weak...
- IleostomyAn opening into the ileum, part of the small intestine, from the outside of the body. An ileostomy provides a...
- IleumThe last part of the small intestine. It connects to the cecum (first part of the large intestine). The ileum...
- IleusBlockage of the intestines
- IlginatinibAn orally bioavailable, small molecule inhibitor of Janus-associated kinase 2 (JAK2) and Src-family kinases...
- IlixadencelAn off-the-shelf immune primer consisting of allogeneic monocyte-derived dendritic cells (MoDCs) that have...
- IloprostA substance that is being studied in the prevention of lung cancer. It belongs to the family of drugs called...
- IlorasertibAn orally bioavailable, adenosine triphospate mimetic, and inhibitor of Aurora kinases, vascular endothelial...
- ILX23-7553A substance that is being studied as an anticancer drug.
- ILX-295501A substance that is being studied as an anticancer drug. It belongs to the family of drugs called...
- IMWithin or into muscle. Also called intramuscular.
- IM-862An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors.
- Image-defined risk factorA term used in the staging of neuroblastoma. It describes certain features of the tumor found on an imaging...
- Image-guided radiation therapyA procedure that uses a computer to create a picture of a tumor to help guide the radiation beam during...
- Imagery therapyA technique in which a person visualizes positive images or scenarios in their mind. During imagery therapy...
- ImagingIn medicine, a process that makes pictures of areas inside the body. Imaging uses methods such as x-rays...
- Imaging agent QRH-882260 heptapeptideAn orally bioavailable fluorescent imaging agent composed of the near-infrared (NIR) fluorophore cyanine 5...
- Imaging procedureA type of test that makes detailed pictures of areas inside the body. Imaging procedures use different forms...
- Imaging testA type of test that makes detailed pictures of areas inside the body. Imaging tests use different forms of...
- ImalumabA human, recombinant monoclonal antibody (MoAb) against macrophage migration inhibitory factor (MIF), with...
- Imatinib mesylateA drug used to treat certain types of leukemia and other blood cancers, gastrointestinal stromal tumors, skin...
- ImbruvicaA drug used alone or with other drugs to treat adults with chronic lymphocytic leukemia, small lymphocytic...
- IMC-1121BA drug that binds to the protein vascular endothelial growth factor (VEGF) to help keep new blood vessels...
- IMC-A12A substance being studied in the treatment of some types of cancer. It is a monoclonal antibody that is made...
- ImdelltraA drug used to treat adults with extensive-stage small cell lung cancer that got worse during or after...
- Imetelstat sodiumA drug used to treat low-risk or intermediate-1 risk myelodysplastic syndromes in adults with anemia. It is...
- ImexonA substance that is being studied in the treatment of some types of cancer, including pancreatic, lung...
- ImfinziA drug that binds to the protein PD-L1 to help immune cells kill cancer cells better and is used to treat...
- ImgatuzumabA glycoengineered monoclonal antibody directed against the epidermal growth factor receptor (EGFR) with...
- Imidazole mustardA synthetic derivative of imidazole with potent antineoplastic properties. Imidazole mustard alkylates DNA...
- Imidazolyl ethanamide pentandioic acidAn orally bioavailable small molecule, with potential hematopoiesis inducing and antiviral activities. Upon...
- ImifoplatinA platinum (Pt)-based agent belonging to the phosphaplatin family comprised of Pt complexed to a...
- ImipenemAn antibiotic drug used to treat severe or very resistant infection. It belongs to the family of drugs called...
- Imipenem-cilastatin-relebactamA parenteral antibiotic preparation containing imipenem, cilastatin sodium and relebactam, with bactericidal...
- ImipramineA synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain...
- ImiquimodA drug used to treat certain skin conditions. Imiquimod is used under the brand names Aldara and Zyclara to...
- Imisopasem manganeseA manganese-based non-peptidyl mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD)...
- ImjudoA drug that binds to the protein CTLA-4 to help immune cells kill cancer cells better and is used to treat...
- ImkeldiA drug used to treat certain types of leukemia and other blood cancers, gastrointestinal stromal tumors, skin...
- ImlunestrantAn orally available selective estrogen receptor degrader (SERD), with potential antineoplastic activity. Upon...
- ImlygicA drug used to treat melanoma that has recurred (come back) after surgery. It is used in patients whose...
- Immature teratomaA type of germ cell tumor that is often made up of several different types of tissue, such as hair, muscle...
- Immediate-release afuresertibAn immediate-release (IR) tablet formulation containing afuresertib, an inhibitor of the serine/threonine...
- Immediate-release bupropionAn immediate-release (IR) tablet formulation of the aminoketone bupropion, with antidepressant activity and...
- Immediate-release onapristoneAn immediate-release (IR) formulation of onapristone, an orally bioavailable progesterone receptor (PR)...
- IMMU-106A substance being studied in the treatment of several types of lymphoma. It binds to the protein CD20, which...
- IMMU-110A substance being studied in the treatment of multiple myeloma and several other types of cancer. It binds to...
- Immune adjuvantA drug that stimulates the immune system to respond to disease.
- Immune cellA cell that is part of the immune system and helps the body fight infections and other diseases. Immune cells...
- Immune checkpoint inhibitorA type of drug that blocks proteins called checkpoints that are made by some types of immune system cells...
- Immune checkpoint proteinA type of protein found on some immune cells, such as T cells and antigen-presenting cells, and some cancer...
- Immune complex hemolytic anemiaA condition in which the body’s immune system stops red blood cells from forming or causes them to clump...
- Immune functionProduction and action of cells that fight disease or infection.
- Immune globulin subcutaneous human-klhwA subcutaneous injectable formulation containing human immune globulins (Ig), mainly IgGs, with a broad...
- Immune responseThe way the body defends itself against substances it sees as harmful or foreign. In an immune response, the...
- Immune systemA complex network of cells, tissues, organs, and the substances they make that helps the body fight...
- Immune system disorderA condition that affects the immune system. The immune system is made up of cells, tissues, and organs that...
- Immune system modulatorA substance that stimulates or suppresses the immune system and may help the body fight cancer, infection, or...
- Immune system toleranceThe failure of the immune system to respond to an antigen that previously caused an immune response.
- Immune thrombocytopeniaA condition in which platelets (blood cells that cause blood clots to form) are destroyed by the immune...
- Immune thrombocytopenic purpuraA condition in which platelets (blood cells that cause blood clots to form) are destroyed by the immune...
- ImmunityIn medicine, the immune system’s way of protecting the body against an infectious disease. The three types of...
- ImmunizationA technique used to cause an immune response that results in resistance to a specific disease, especially an...
- Immunoadjuvant QS-DGA synthetic saponin, chemically identical to the natural saponin QS-21, with immunoadjuvant activity. When...
- ImmunoassayA test that uses the binding of antibodies to antigens to identify and measure certain substances...
- Immunoassay fecal occult blood testA test that checks for occult (hidden) blood in the stool. A small sample of stool is placed in a special...
- Immunochemical fecal occult blood testA test that checks for occult (hidden) blood in the stool. A small sample of stool is placed in a special...
- ImmunocompetenceThe ability to produce a normal immune response.
- ImmunocompetentHaving the ability to produce a normal immune response.
- ImmunocompromisedHaving a weakened immune system. People who are immunocompromised have a reduced ability to fight infections...
- ImmunoconjugateAn agent made up of an immune substance, such as a monoclonal antibody, that is chemically linked to a...
- Immunoconjugate therapyA type of treatment that uses an immune substance, such as a monoclonal antibody, that is chemically linked...
- ImmunocytochemistryA laboratory method that uses antibodies to check for certain antigens (markers) in a sample of cells. The...
- Immunocytokine NHS-IL12A fusion protein consisting of the heavy-chains of the human antibody NHS76, raised against DNA released by...
- Immunocytokine NHS-IL2-LTA fusion protein consisting of a mouse-human chimeric antibody directed against DNA released by necrotic...
- ImmunodeficiencyThe decreased ability of the body to fight infections and other diseases.
- Immunodeficiency syndromeThe inability of the body to produce an immune response.
- ImmunofluorescenceA method used in the lab to detect certain antigens (markers) on a cell or in a tissue sample...
- Immunogenic cell death inducer CAN2109A long-acting, bi-functional immunogenic cell death (ICD) inducer, with potential immunostimulating and...
- ImmunogenicityThe ability of a substance that contains antigens to cause the body to make an immune response against that...
- ImmunoglobulinA protein that is made by B cells and plasma cells (types of white blood cells) and helps the body fight...
- Immunohemolytic anemiaA condition in which the body’s immune system stops red blood cells from forming or causes them to clump...
- ImmunohistochemistryA laboratory method that uses antibodies to check for certain antigens (markers) in a sample of tissue. The...
- Immunologic fecal occult blood testA test that checks for occult (hidden) blood in the stool. A small sample of stool is placed in a special...
- Immunological adjuvantA substance used to help boost the immune response to a vaccine so that less vaccine is needed.
- ImmunologyThe study of the body's immune system.
- Immunomodulating agentA substance that stimulates or suppresses the immune system and may help the body fight cancer, infection, or...
- ImmunomodulationChange in the body's immune system, caused by agents that activate or suppress its function.
- Immunomodulator LAM-003An orally bioavailable immunomodulating agent with potential antineoplastic activity
- Immunomodulator OHR/AVR118A peptide-nucleic acid immunomodulator with proinflammatory, broad-spectrum antiviral, and potential...
- Immunomodulatory agent CC-11006A proprietary, orally available, small molecule and thalidomide analog, with potential immunomodulating and...
- ImmunophenotypingA process that uses antibodies to identify cells based on the types of antigens or markers on the surface of...
- ImmunoscintigraphyAn imaging procedure in which antibodies labeled with radioactive substances are given to the person. A...
- ImmunosignatureInformation about the antibodies in a person’s blood at a given point in time. Over time, the antibodies can...
- ImmunostimulantA substance that increases the ability of the immune system to fight infection and disease.
- ImmunosuppressedHaving a weakened immune system. People who are immunosuppressed have a reduced ability to fight infections...
- ImmunosuppressionSuppression of the body's immune system and its ability to fight infections and other diseases...
- ImmunosuppressiveDescribes the ability to decrease the body's immune system responses.
- Immunosuppressive agentAn agent that decreases the body’s immune responses. It reduces the body’s ability to fight infections and...
- Immunosuppressive therapyTreatment that lowers the activity of the body’s immune system. This reduces its ability to fight infections...
- Immunotherapeutic combination product CMB305An immunotherapeutic combination product composed of LV305, an engineered lentiviral vector that both targets...
- Immunotherapeutic gel SRG-514An injectable biodegradable hydrogel, with potential immunostimulating and antineoplastic activities. Upon...
- ImmunotherapyA type of therapy that uses substances to stimulate or suppress the immune system to help the body fight...
- Immunotherapy regimen MKC-1106-MTAn immunotherapy regimen containing three components: a plasmid encoding portions of the two...
- ImmunotoxinAn immune substance, such as a monoclonal antibody, cytokine, or immunoglobulin, chemically linked to a toxic...
- Immunotoxin CMD-193A humanized immunotoxin directed against the Lewis Y antigen conjugated with calicheamicin, a hydrophobic...
- Immunotoxin D2C7-(scdsFv)-PE38KDELA recombinant immunotoxin fusion protein consisting of single-chain variable-region antibody fragments...
- ImodiumA drug used to treat diarrhea. Imodium works by binding to mu opioid receptors in the intestines, which slows...
- ImofinostatAn orally bioavailable N-hydroxyacrylamide-derived inhibitor of both human pan-histone deacetylase (HDAC)...
- ImpairmentA loss of part or all of a physical or mental ability, such as the ability to see, walk, or learn.
- ImplantA substance or object that is put in the body as a prosthesis, or for treatment or diagnosis.
- Implant displacement viewsA procedure used to do a mammogram (x-ray of the breasts) in women with breast implants. The implant is...
- Implant radiation therapyA type of radiation therapy in which radioactive implants, such as pellets, seeds, ribbons, wires, needles...
- Implantable cardioverter-defibrillatorA small device used to correct a heartbeat that is abnormal (too fast, too slow, or irregular). The device is...
- Implantable pumpA small device installed under the skin to administer a steady dose of drugs.
- ImpotenceIn medicine, refers to the inability to have an erection of the penis adequate for sexual intercourse. Also...
- ImpotentIn medicine, describes the inability to have an erection of the penis adequate for sexual intercourse.
- IMREG-1A low molecular weight fraction of human leukocyte dialysates with potential immunostimulatory activity...
- IMRTA type of 3-dimensional radiation therapy that uses computer-generated images to show the size and shape of...
- ImsidolimabA humanized monoclonal antibody directed against the interleukin-36 receptor (IL-36R), with potential...
- IMT-1012 immunotherapeutic vaccineA multi-peptide cancer vaccine with potential immunostimulating and antineoplastic activities. IMT-1012...
- In 111 monoclonal antibody B3A radioimmunoconjugate of monoclonal antibody (MoAb) B3 labeled with Indium 111 (In-111). MoAb B3 is a murine...
- In 111 monoclonal antibody Hu3S193A radioimmunoconjugate of humanized monoclonal antibody (MoAb) 3S193 labelled with Indium 111 (In-111). MoAb...
- In situIn its original place. For example, in carcinoma in situ, abnormal cells are found only in the place where...
- In vitroIn the laboratory (outside the body). The opposite of in vivo (in the body).
- In vitro fertilizationA procedure in which eggs are removed from a woman’s ovary and combined with sperm outside the body to form...
- In vivoIn the body. The opposite of in vitro (outside the body or in the laboratory).
- Inactivated oncolytic virus particle GEN0101An inactivated, non-replicating particle of hemagglutinating virus of Japan (HVJ), an oncolytic virus of the...
- Inactivated poliovirus vaccineA vaccine consisting of inactivated poliovirus (IPV) types 1,2 and 3, with active immunizing activity against...
- InalimarevA cancer vaccine made with a form of vaccinia virus that does not cause disease in humans. It is being...
- InavolisibA drug used with palbociclib and fulvestrant to treat adults with certain types of hormone-receptor positive...
- IncidenceThe number of new cases of a disease diagnosed each year.
- IncisionA cut made in the body to perform surgery.
- Incisional biopsyA surgical procedure in which a cut is made through the skin to remove a sample of abnormal tissue or part of...
- InclusionBeing part of something. Can also refer to creating an environment that encourages a person or group to feel...
- Incomplete colonoscopyA colonoscopy that was attempted but could not be completed. A colonoscopy is an examination of the inside of...
- Incomplete Freund's adjuvantA mixture of oil and water that is combined with a specific antigen to boost the immune response to that...
- Incomplete penetranceA term that describes when some people with a disease-causing mutation (change) in a gene develop the disease...
- Inconclusive resultA negative test result in an individual where a clearly deleterious mutation has not been found in any family...
- IncontinenceInability to control the flow of urine from the bladder (urinary incontinence) or the escape of stool from...
- IncubatedGrown in the laboratory under controlled conditions. For example, white blood cells can be grown in special...
- IncyclinideA chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix...
- INDA substance that has been tested in the laboratory and has been approved by the U.S. Food and Drug...
- InderalA drug that contains the active ingredient propranolol hydrochloride and is used to treat high blood...
- Indeterminate resultA negative test result in an individual where a clearly deleterious mutation has not been found in any family...
- India inkAn aqueous suspension containing carbon particulates from charcoal powder and paramagnetic oxygen (O2)...
- Indian cressParts of the flowering plant have been used in some cultures to treat certain medical problems. It may have...
- Indian elmThe inner bark of this plant has been used in some cultures to treat certain medical problems. It may have...
- Indian rhubarbThe root of this plant has been used in some cultures to treat certain medical problems. It may have...
- Indian saffronAn East Indian plant that is a member of the ginger family and is used as a spice and food color. It is a...
- Indian valerianA plant whose roots are used as a sedative and to treat certain medical conditions. It is being studied as a...
- IndibulinA synthetic small molecule with antimitotic and potential antineoplastic activities. Indibulin binds to a...
- IndicationIn medicine, a sign, symptom, or medical condition that leads to the recommendation of a treatment, test, or...
- indicine-N-oxideA natural pyrrolizidine alkaloid with antineoplastic properties. Indicine-N-oxide alkylates and crosslinks...
- Indigotindisulfonate sodiumThe sodium salt form of indigotindisulfonate, a synthetic blue dye and food colorant derived from indigo...
- IndinavirA drug that interferes with the ability of a virus to make copies of itself.
- Indinavir sulfateA synthetic antiviral agent. Indinavir selectively binds to the active site of human immunodeficiency virus...
- Indirect ophthalmoscopyAn exam of the inside of the back of the eye using a beam of light and a hand-held lens. Indirect...
- Indium In 111 anti-CD45 monoclonal antibody BC8A radioimmunoconjugate containing the murine IgG1 anti-CD45 monoclonal antibody (MoAb) BC8 labeled with the...
- Indium In 111 anti-EGFR monoclonal antibody ABT-806A radioimmunoconjugate composed of a humanized monoclonal antibody IgG1 directed against the epidermal growth...
- Indium In 111 bevacizumabA radioimmunoconjugate comprised of the recombinant humanized monoclonal antibody bevacizumab conjugated with...
- Indium In 111 capromab pendetideA radioimmunoconjugate consisting of the murine IgG1 kappa monoclonal antibody capromab (7E11-C5.3)...
- Indium In 111 chimeric monoclonal antibody 806A recombinant chimeric, mouse-human monoclonal antibody IgG1, directed against the epidermal growth factor...
- Indium In 111 FPI-2058A radioconjugate consisting of the neurotensin receptor type 1 (NTR1; NTSR1) antagonist, IPN01087 (3BP-227)...
- Indium In 111 FPI-2071A radioimmunoconjugate composed of FPI-2053, a humanized bispecific antibody targeting epidermal growth...
- Indium In 111 minigastrin analog CP04A radioconjugate consisting of the minigastrin analog, CP04, labeled with the gamma-emitting radioisotope...
- Indium In 111 monoclonal antibody BrE-3A humanized monoclonal antibody conjugated to the imaging radioisotope (indium-111). This...
- Indium In 111 monoclonal antibody HuJ591A radioimmunoconjugate containing the recombinant humanized monoclonal antibody J591 directed against the...
- Indium In 111 monoclonal antibody huPAM4The humanized monoclonal antibody huPAM4, directed against the pancreatic cancer antigen MUC-1 and...
- Indium In 111 panitumumabA radioimmunoconjugate composed of panitumumab, a human immunoglobulin G2 (IgG2) monoclonal antibody directed...
- Indium In 111 pentetateA sterile, non-pyrogenic, isotonic solution of radioactive indium In 111 diethylenetriamine pentaacetate...
- Indium In 111 pertuzumabA radioimmunoconjugate composed of a humanized recombinant monoclonal antibody directed against the...
- Indium In 111 tabituximab barzuxetanA radioconjugate consisting of tabituximab, a humanized immunoglobulin G1 (IgG1) monoclonal antibody directed...
- Indium In 111 vofatamabA radioimmunoconjugate composed of vofatamab, a human immunoglobulin G1 (IgG1) monoclonal antibody directed...
- Indium In 111-ABD147A radioimmunoconjugate consisting of ABD147, an antibody fragment directed against the tumor-associated...
- Indium In 111-anti-CEA monoclonal antibody M5AA substance being studied in the imaging of some types of cancer. M5A is a monoclonal antibody that binds to...
- Indium In 111-autologous CMV-pp65-LAMP mRNA-loaded dendritic cellsA radioimmunoconjugate composed of mature autologous dendritic cells (DCs) generated from peripheral blood...
- Indium In 111-CHX-A DTPA trastuzumabA substance being studied in the imaging of breast cancer and some other types of cancer. It is made by...
- Indium In 111-CMD-193A radiolabeled antibody-targeted antineoplastic antibiotic consisting of the enediyne antibiotic...
- Indium In 111-DOTA-basiliximabA radioimmunoconjugate composed of basiliximab, a chimeric, mouse-human monoclonal antibody directed against...
- Indium In 111-DOTA-biotinA radioimmunoconjugate of biotin conjugated with the bifunctional, macrocyclic chelating agent...
- Indium In 111-DOTA-daratumumabA radioimmunoconjugate containing daratumumab, a human immunoglobulin G1 kappa (IgG1k) monoclonal antibody...
- Indium In 111-DOTA-exendin-4A radiopharmaceutical composed of the glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4 linked by...
- Indium In 111-DOTA-girentuximabA radioimmunoconjugate comprised of the chimeric monoclonal antibody girentuximab conjugated with the...
- Indium In 111-DOTA-h11B6A radioimmunoconjugate containing the recombinant immunoglobulin G1 (IgG1) kappa humanized monoclonal...
- Indium In 111-FL-020A radioconjugate composed of FL-020, a human prostate-specific membrane antigen (PSMA)-targeting ligand...
- Indium In 111-FPI-1547A radioimmunoconjugate composed of FPI-1175 (AVE1642), a humanized monoclonal antibody against insulin-like...
- Indium In 111-ibritumomab tiuxetanA radiolabeled monoclonal antibody used to find certain types of B-cell non-Hodgkin lymphoma. It is also...
- Indium In 111-labeled autologous peripheral blood mononuclear cellsA preparation of autologous peripheral blood mononuclear cells (PBMCs) radiolabeled with indium In 111 with...
- Indium In 111-labeled autologous polymorphonuclear leukocytesA preparation of autologous peripheral polymorphonuclear (PMNLs) radiolabeled with indium In 111 with...
- Indium In 111-pentetreotideA radioactive drug used to find certain types of neuroendocrine tumors (tumors that form from cells that...
- Indium In 111-XYIMSR-01A radioconjugate consisting of XYIMSR-01, a bivalent low molecular weight ligand targeting two separate sites...
- Indium In-111-DOTA-di-HSG peptide IMP-288A radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with the macrocyclic chelator...
- Individualized education planAn education plan for children with certain disabilities or health conditions, such as cancer. By law, these...
- Individualized MVA-based vaccine TG4050An off-the-shelf (OTS) individualized vaccine comprised of a modified Vaccinia virus Ankara (MVA) viral...
- Indocyanine green solutionA sterile solution of a nontoxic tricarbocyanine dye with a peak spectral absorption at 790 nm, with...
- Indocyanine green/albumin solutionA solution containing a non-toxic, fluorescent tricarbocyanine dye with a peak spectral absorption at 790 nm...
- IndoleA type of chemical found in plants and in certain vegetables, such as broccoli, cabbage, and cauliflower...
- indole-3-carbinolA substance that is being studied as a cancer prevention drug. It is found in cruciferous vegetables.
- indole-3-carbinol/calcium/Schizandra/vitamin D3/milk thistle/stinging nettle/lignan-based nutritional capsuleAn orally available capsule-based nutritional supplement containing indole-3-carbinol, calcium-D-glucarate...
- Indoleamine 2,3-dioxygenase peptide vaccineA peptide vaccine against the immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO), with potential...
- IndolentA type of cancer that grows slowly.
- Indolent lymphomaA type of lymphoma that tends to grow and spread slowly, and has few symptoms. Also called low-grade lymphoma.
- IndomethacinA drug that reduces pain, fever, swelling, and redness. It is also being used to reduce tumor-induced...
- IndoximodA methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine...
- Indoximod prodrug NLG802An orally bioavailable prodrug of indoximod, a methylated tryptophan, with immune checkpoint inhibitory and...
- Inducible CD4+CD25+ regulatory T cellsInducible regulatory T-lymphocytes that express CD4, CD25 (the alpha chain of the interleukin 2 receptor) and...
- Induction therapyThe first treatment given for a disease. It is often part of a standard set of treatments, such as surgery...
- Industrial hempAn herb that comes from a variant of the Cannabis sativa plant and contains fiber, seeds, and oil used to...
- InebilizumabA humanized immunoglobulin IgG1 kappa monoclonal antibody directed against the B-cell-specific membrane...
- InecalcitolAn analog of calcitriol and a vitamin D3 receptor (VDR) agonist, with potential antineoplastic activity. Upon...
- InetetamabAn Fc-engineered monoclonal antibody targeting the tyrosine kinase receptor epidermal growth factor receptor...
- Infantile fibrosarcomaA type of cancer that forms in fibrous (connective) tissue. Infantile fibrosarcoma usually occurs in infants...
- Infantile genetic agranulocytosisAn inherited disorder in which there is a lower-than-normal number of neutrophils (a type of white blood cell...
- Infantile hemangiomaA benign (not cancer) blood vessel tumor that forms on the skin, in the tissue below the skin, or in an...
- Infantile hemangiopericytomaA rare type of soft tissue tumor that begins in cells that wrap around blood vessels. Infantile...
- Infantile myofibromatosisA rare condition in which one or more fibrous (connective tissue) tumors form in the skin, muscle, or bone...
- Infantile ricketsA condition in children in which bones become soft and deformed because they don’t have enough calcium and...
- InfectionThe invasion and growth of germs in the body. The germs may be bacteria, viruses, yeast, fungi, or other...
- Inferior vena cavaA large vein that empties into the heart. It carries blood from the legs and feet and from organs in the...
- InfertileUnable to produce children.
- InfertilityThe inability to produce children.
- Infigratinib phosphateThe phosphate salt form of infigratinib, an orally bioavailable pan-inhibitor of human fibroblast growth...
- Infiltrating breast cancerCancer that has spread from where it began in the breast to surrounding normal tissue. The most common type...
- Infiltrating cancerCancer that has spread beyond the layer of tissue in which it developed and is growing into surrounding...
- Infiltrating ductal carcinomaThe most common type of infiltrating breast cancer. It begins in the lining of the milk ducts (thin tubes...
- Infiltrating lobular carcinomaA type of invasive breast cancer that begins in the lobules (milk glands) of the breast and spreads to...
- InflammationA normal part of the body’s response to injury or infection. Inflammation occurs when the body releases...
- InflammatoryHaving to do with inflammation (redness, swelling, pain, and a feeling of heat that helps protect tissues...
- Inflammatory bowel diseaseA general term that refers to the inflammation of the colon and rectum. Inflammatory bowel disease includes...
- Inflammatory breast cancerA rare, fast-growing type of breast cancer in which cancer cells block lymph vessels in the skin of the...
- Inflammatory myofibroblastic tumorA rare type of cancer that is made up of smooth muscle cells, connective tissue cells, and certain types of...
- InfliximabA monoclonal antibody that blocks the action of a cytokine called tumor necrosis factor alfa. It is being...
- Influenza A virusOne of three types of virus that cause the illness called influenza (flu). The influenza A virus can infect...
- InformativeIn genetic testing, a test result that reveals definitively the presence or absence of the germline genetic...
- Informed consentA process in which patients are given important information, including possible risks and benefits, about a...
- Infrared coagulationA technique in which abnormal tissue is exposed to a burst of infrared light (a type of radiation). This...
- Infrared thermographyIn medicine, a procedure in which an infrared camera (one that senses heat) is used to measure temperature...
- InfratentoriumThe lower back part of the brain that contains the cerebellum and brain stem. Examples of tumors that form in...
- InfugemA drug used alone or with other drugs to treat certain types of breast, non-small cell lung, ovarian, and...
- InfusionA method of putting fluids, including drugs, into the bloodstream. Also called intravenous infusion.
- Ingenol derivative LEO 43204 gelA topical, aqueous gel formulation containing a derivative of ingenol, a selective small-molecule activator...
- Ingenol mebutateA selective small-molecule activator of protein kinase C (PKC) isolated from the plant Euphorbia peplus with...
- Ingenol mebutate gelA drug applied to the skin to treat actinic keratosis (thick, scaly growths on the skin that may become...
- IngestionTaking into the body by mouth.
- Inguinal orchiectomyAn operation in which the testicle is removed through an incision in the groin.
- InhalationIn medicine, refers to the act of taking a substance into the body by breathing.
- Inhaled voriconazoleAn inhaled formulation of voriconazole, a synthetic triazole with antifungal activity. Upon administration by...
- InhalerA device for giving medicines in the form of a spray that is inhaled (breathed in) through the nose or mouth...
- InheritedIn medicine, describes the passing of genetic information from parent to child through the genes in sperm and...
- Inherited bone marrow failure syndromeA rare disorder in which a person’s bone marrow is unable to make enough blood cells and there is a family...
- Inherited cancer syndromeA type of inherited disorder in which there is a higher-than-normal risk of certain types of cancer...
- Inherited erythroblastopeniaA very rare disorder in which the bone marrow doesn’t make enough red blood cells. It is usually seen in the...
- Inherited predispositionAn inherited increase in the risk of developing a disease. Also called genetic predisposition, genetic...
- IniparibA substance being studied in the treatment of some types of cancer. Iniparib may kill cancer cells. Also...
- Injectable Astragalus membranaceus polysaccharideAn injectable form of a polysaccharide isolated from the radix of Astragalus membranaceus (PG2), used in...
- InjectionUse of a syringe and needle to push fluids or drugs into the body; often called a "shot."
- iNKT cell agonist ABX196A synthetic glycolipid agonist for natural killer T cells (NKTs) expressing an invariant (alpha, beta) T-cell...
- InlytaA drug used alone or with other drugs to treat advanced renal cell carcinoma (a type of kidney cancer). It is...
- Innate defense regulator SGX942A synthetic, 5-amino acid peptide and innate defense regulator (IDR), with immunomodulating...
- Innate immunityImmunity that is present at birth and lasts a person’s entire life. Innate immunity is the first response of...
- Innate immunostimulator rBBX-01A recombinant 19 kDa protein derived from the Apicomplexa protozoan Eimeria with potential immunostimulating...
- InnohepA drug that is used with another drug, warfarin, to treat blood clots that form deep in the veins and to...
- INO-1001A isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP)...
- Inodiftagene vixteplasmidA recombinant DNA plasmid carrying the gene for diphtheria toxin-A (dT-A) chain under the regulation of the...
- InoperableDescribes a condition that cannot be treated by surgery.
- Inosine 5'- monophosphate dehydrogenase inhibitor FF-10501-01An orally bioavailable inhibitor of inosine 5'- monophosphate dehydrogenase (IMPDH), with potential...
- Inosine dialdehydeA toxic purine analogue. Inosine dialdehyde inhibits ribonucleotide reductase, resulting in decreased...
- Inosine pranobexA formulation containing inosine, 4-acetamidobenzoic Acid, and N,N-dimethylaminoisopropanol, with...
- InositolA nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy...
- Inositol hexaphosphateA substance found in many foods that come from plants, including corn, wheat, rice, and soybeans, and in...
- InotersenAn antisense oligonucleotide (ASO) targeting transthyretin (TTR), which has potential use in the treatment of...
- Inotuzumab ozogamicinA drug used to treat adults and children aged 1 year and older with B-cell acute lymphoblastic leukemia that...
- InqoviA combination of decitabine and cedazuridine used to treat adults with myelodysplastic syndromes, including...
- InrebicA drug used to treat adults with intermediate-risk or high-risk myelofibrosis (MF), including primary MF...
- INS316A substance being studied in the diagnosis of lung diseases, including lung cancer. It helps bring up a...
- InsertionA type of genetic change that involves the addition of a segment of DNA. It may be as small as a single base...
- InsomniaDifficulty in going to sleep or getting enough sleep.
- InstillationIn medicine, a method used to put a liquid into the body slowly or drop by drop.
- Institutional Review BoardA group of scientists, doctors, clergy, and patient advocates that reviews and approves the detailed plan for...
- InsulinA hormone made by the islet cells of the pancreas. Insulin controls the amount of sugar in the blood by...
- Insulin glargineA drug used to control the amount of sugar in the blood of patients with diabetes. It is a form of the...
- Insulin glargine recombinantA drug used to control the amount of sugar in the blood of patients with diabetes. It is a form of the...
- Insulin glulisineA drug used to control the amount of sugar in the blood of patients with diabetes mellitus. It is a form of...
- Insulin lisproA recombinant therapeutic agent which is chemically identical to or similar to endogenous human insulin. In...
- Insulin, NPHAn intermediate-acting insulin used in the treatment of diabetes mellitus. Administered once or twice daily...
- Insulin, regularA recombinant form of the naturally occurring human pancreatic hormone insulin. Upon administration, regular...
- Insulin sensitizer S-707106An orally available protein and insulin sensitizer with anti-hyperglycemic activity. Upon oral...
- Insulin-like growth factorA protein made by the body that stimulates the growth of many types of cells. Insulin-like growth factor is...
- Insulin-like growth factor receptorA protein found on the surface of some types of cells that binds to insulin-like growth factor (IGF). This...
- InsulinomaAn abnormal mass that grows in the beta cells of the pancreas that make insulin. Insulinomas are usually...
- Integrative medicineAn approach to medical care that recognizes the benefit of combining conventional (standard) therapies (such...
- IntegrinA type of protein found on the surface of cells that helps them attach to, and communicate with, nearby...
- Integrin alpha-2 inhibitor E7820A small molecule and aromatic sulfonamide derivative with potential antiangiogenic and antitumor activities...
- Integrin alphaVbeta3-targeted small molecule-drug conjugate VIP236A small molecule-drug conjugate (SMDC) composed of an integrin alphaVbeta3 binder conjugated, via a cleavable...
- Integrin receptor antagonist GLPG0187A small molecule integrin receptor antagonist (IRA) with potential antineoplastic activity. Upon...
- Intensification therapyTreatment that is given after cancer has disappeared following the initial therapy. Intensification therapy...
- Intensity-modulated radiation therapyA type of 3-dimensional radiation therapy that uses computer-generated images to show the size and shape of...
- Intensive chemotherapyTreatment that uses anticancer drugs given at high doses or over several months to try to cure cancer or...
- Intercellular communicationThe transfer of information from one cell to another. Cells signal each other by direct contact with each...
- Interfering thoughtAn unpleasant memory or idea that occurs often in a person’s everyday thoughts and keeps him or her from...
- InterferonA natural substance that helps the body’s immune system fight infection and other diseases, such as cancer...
- Interferon alfa-2bA drug used alone or with other drugs to treat adults with AIDS-related Kaposi sarcoma, hairy cell leukemia...
- Interferon alfacon-1An analogue of consensus interferon which contains an additional methionyl amino acid residue. Consensus...
- Interferon beta-secreting mesenchymal stem cellsHuman autologous mesenchymal stem cells (MSCs) harvested from the bone marrow of healthy individuals and...
- Interferon gamma-1bA recombinant form of the endogenous cytokine interferon-gamma (IFN-gamma; IFNg), with a peptide length of...
- Interferon gamma-primed human bone marrow-derived mesenchymal stromal cellsHuman bone marrow-derived mesenchymal stromal cells (MSCs) primed with interferon gamma (IFN-g), with...
- Interferon-gamma-expressing adenovirus vaccine ASN-002A replication-defective adenoviral serotype 5 vector encoding a recombinant form of the human cytokine...
- InterleukinOne of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- interleukin-1One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- interleukin-10One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- interleukin-11One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- interleukin-12One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- interleukin-12 geneThe DNA sequence that encodes the protein cytokine interleukin-12 (IL-12). When introduced as the...
- interleukin-12-Fc fusion protein DF6002A fusion protein composed of human Interleukin-12 (IL-12) fused to a Fc fragment, with potential...
- interleukin-13One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- interleukin-13 PE38QQR immunotoxinA substance being studied in the treatment of cancer. It is made by combining interleukin-13 with a toxin...
- interleukin-15 agonist fusion protein SHR1501A human Fc fusion protein composed of the cytokine interleukin (IL)-15 cross-linked with the high-affinity...
- interleukin-15 fusion protein BJ-001A human fusion protein composed of the cytokine interleukin (IL)-15 linked with an integrins-targeting...
- interleukin-15/interleukin-15 receptor alpha complex-Fc fusion protein XmAb24306An interleukin (IL)-15/IL-15-receptor alpha (IL-15Ra) complex fused to a bispecific Fc domain, with potential...
- interleukin-1-alfaOne of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- interleukin-1-alphaOne of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- interleukin-1-betaOne of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- interleukin-2One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- interleukin-2 geneThe DNA sequence that encodes the protein cytokine interleukin-2 (IL-2). When introduced as the complementary...
- interleukin-2/interleukin-15 receptor agonist NL-201An interleukin-2 (IL-2) and interleukin-15 (IL-15) receptor agonist with high binding affinity for the common...
- interleukin-3One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- interleukin-4One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- interleukin-4 PE38KDEL cytotoxinA substance being studied in the treatment of cancer. It is made by combining interleukin-4 with a bacterial...
- interleukin-4 PE38KDEL immunotoxinA substance being studied in the treatment of cancer. It is made by combining interleukin-4 with a bacterial...
- interleukin-5One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- interleukin-6One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- interleukin-7One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body...
- Intermediate gradeA term used to describe how abnormal cancer cells look under a microscope. Intermediate-grade cancer cells...
- Intermediate-grade DCISA condition in which cells that look somewhat abnormal under a microscope are found in the lining of a breast...
- Intermediate-grade ductal carcinoma in situA condition in which cells that look somewhat abnormal under a microscope are found in the lining of a breast...
- Intermediate-grade lymphomaA type of lymphoma that grows and spreads quickly and has severe symptoms. Also called aggressive lymphoma...
- Internal examA physical exam of the vulva, vagina, cervix, uterus, fallopian tubes, ovaries, and rectum. First, the vulva...
- Internal medicineA branch of medicine that specializes in preventing, diagnosing, and treating diseases in adults, without...
- Internal radiation therapyA type of radiation therapy in which a source of radiation is put inside the body. Brachytherapy is a type...
- Internal tandem duplicationA type of genetic change in which a DNA sequence in a gene is copied and inserted right after the original...
- Internalized-arginylglycylaspartic acid cyclic peptideA 9 amino acid-based cyclic, tumor specific homing, arginine-glycine-aspartic acid (RGD)-based peptide...
- International UnitA unit used to measure the activity of many vitamins, hormones, enzymes, and drugs. An International Unit is...
- InternistA doctor who has special training in internal medicine. An internist works with adult patients to prevent...
- Interstitial cell-stimulating hormoneA hormone made in the pituitary gland. In females, it acts on the ovaries to make follicles release their...
- Interstitial fluidFluid found in the spaces around cells. It comes from substances that leak out of blood capillaries (the...
- Interstitial radiation therapyA type of internal radiation therapy in which radioactive material sealed in needles, seeds, wires, or...
- Interval breast cancerBreast cancer that is diagnosed during the time between a regular screening mammogram that appears normal and...
- InterventionIn medicine, a treatment, procedure, or other action taken to prevent or treat disease, or improve health in...
- Intervention groupThe group in a clinical research study that receives the drug, vaccine, or other intervention being tested...
- IntestinalHaving to do with the intestines.
- Intestinal floraBacteria and other organisms that live inside the intestines. They help digest food. Vitamins such as biotin...
- Intestinal microfloraBacteria and other organisms that live inside the intestines. They help digest food. Vitamins such as biotin...
- Intestinal obstructionA partial or complete block of the small or large intestine that keeps food, liquid, gas, and stool from...
- Intestinal villiTiny hair-like projections that line the inside of the small intestine. They contain blood vessels and help...
- IntestineThe long, tube-shaped organ in the abdomen that completes the process of digestion. The intestine has two...
- IntetumumabA pan alpha-v human monoclonal antibody that recognizes alpha-v beta-1, alpha-v beta-3, alpha-v beta-5, and...
- IntoplicineA substance that has been studied in the treatment of some types of cancer. Intoplicine blocks certain...
790 of 17,717 terms in Oncology and biomedicine terminology (MLC-0111). Request the full dataset.