indole-3-carbinol

{
  "id": "MLC-T-ONC-004286",
  "term": "indole-3-carbinol",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance that is being studied as a cancer prevention drug. It is found in cruciferous vegetables.",
    "A naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, a natural compound present in a wide variety of plant food substances including members of the family Cruciferae with antioxidant and potential chemopreventive properties. Indole-3-carbinol scavenges free radicals and induces various hepatic cytochrome P450 monooxygenases. Specifically, this agent induces the hepatic monooxygenase cytochrome P4501A1 (CYP1A1), resulting in increased 2-hydroxylation of estrogens and increased production of the chemoprotective estrogen 2-hydroxyestrone."
  ],
  "abbreviation": "I3C",
  "synonyms": [
    "indole-3-methanol",
    "3-hydroxymethylindole"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indole-3-carbinol/"
}