Indoleamine 2,3-dioxygenase peptide vaccine

{
  "id": "MLC-T-ONC-014444",
  "term": "Indoleamine 2,3-dioxygenase peptide vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A peptide vaccine against the immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO), with potential immunomodulating and antineoplastic activities. Vaccination with indoleamine 2,3-dioxygenase peptide vaccine may activate the immune system to induce an immune response against IDO-expressing cells. This may increase and restore the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T-lymphocytes, and may eradicate IDO-expressing tumor cells. IDO, a cytosolic enzyme responsible for tryptophan catabolism and conversion of tryptophan into kynurenine, is overexpressed by a variety of tumor cell types and antigen presenting cells (APCs) and plays an important role in immunosuppression; tryptophan depletion inhibits T-lymphocyte proliferation and activation, and suppresses the immune system.",
  "abbreviation": "IDO peptide vaccine",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indoleamine-23-dioxygenase-peptide-vaccine/"
}