Indium In 111 panitumumab

{
  "id": "MLC-T-ONC-014420",
  "term": "Indium In 111 panitumumab",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate composed of panitumumab, a human immunoglobulin G2 (IgG2) monoclonal antibody directed against the epidermal growth factor receptor (EGFR; HER1; ErbB1), labeled with the radioisotope indium In 111, with potential use as an imaging agent upon single photon emission computed tomography/computed tomography (SPECT/CT). Upon administration of Indium In 111 panitumumab, the antibody moiety targets and binds to the extracellular domain of EGFR on tumor cells. Upon SPECT/CT imaging, EGFR-expressing tumor cells can be visualized and assessed. EGFR, a receptor tyrosine kinase overexpressed on the cell surfaces of many tumor cell types, plays a key role in tumor cell proliferation.",
  "synonyms": [
    "111In-panitumumab",
    "111In panitumumab",
    "In 111-panitumumab"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indium-in-111-panitumumab/"
}