Indium In 111-FL-020

{
  "id": "MLC-T-ONC-014434",
  "term": "Indium In 111-FL-020",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of FL-020, a human prostate-specific membrane antigen (PSMA)-targeting ligand, conjugated to the radioisotope indium In 111, with potential imaging activity during single photon emission computed tomography (SPECT)/computed tomography (PET/CT). Upon administration of indium In 111-FL-020, FL-020 targets and binds to PSMA-expressing tumor cells, followed by internalization and retention of the radioisotope. This allows for imaging of PSMA-expressing tumor cells using gamma scintigraphy. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors.",
  "synonyms": [
    "[111In]-FL-020",
    "[111In]In-FL-020",
    "indium In 111 FL-020",
    "indium In 111-labeled FL-020"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indium-in-111-fl-020/"
}