indium In 111-DOTA-h11B6

{
  "id": "MLC-T-ONC-014433",
  "term": "indium In 111-DOTA-h11B6",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate containing the recombinant immunoglobulin G1 (IgG1) kappa humanized monoclonal antibody h11B6 that targets human kallikrein-2 (HK2) conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with the radioisotope indium In 111, with potential use as an imaging agent. Upon administration of indium In 111-DOTA-h11B6, the h11B6 moiety targets and binds to HK2. Upon binding and radioimaging, HK2-expressing tumor cells can be visualized and the binding of h11B6 can be assessed. HK2 is overexpressed on a variety of cancer cells.",
  "synonyms": [
    "111In-DOTA-h11B6",
    "indium-111 radiolabeled h11B6"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indium-in-111-dota-h11b6/"
}