indium In 111-DOTA-daratumumab

{
  "id": "MLC-T-ONC-014430",
  "term": "indium In 111-DOTA-daratumumab",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate containing daratumumab, a human immunoglobulin G1 kappa (IgG1k) monoclonal antibody directed against the cell surface glycoprotein CD38, conjugated to the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), and labeled with the radioisotope indium In 111, with potential use as an imaging agent. Upon administration, the monoclonal antibody moiety of indium In 111-DOTA-daratumumab specifically targets and binds to cell surface antigen CD38. Upon binding and gamma scintigraphy, CD38-expressing tumor cells can be visualized, and the binding and biodistribution of daratumumab can be assessed. CD38, a cell surface glycoprotein, is expressed on various hematopoietic cells and is overexpressed on multiple myeloma (MM) cells.",
  "synonyms": [
    "111In-DOTA-daratumumab"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indium-in-111-dota-daratumumab/"
}