indium In 111-DOTA-exendin-4

{
  "id": "MLC-T-ONC-014431",
  "term": "indium In 111-DOTA-exendin-4",
  "field": "Oncology and biomedicine",
  "definition": "A radiopharmaceutical composed of the glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4 linked by the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the positron-emitting radionuclide indium In 111, with potential use in diagnostic imaging upon positron emission tomography (PET). Upon administration of indium In 111-DOTA-exendin-4, the exendin-4 moiety binds to GLP-1R and is subsequently internalized. The radionuclide moiety can be detected using PET and GLP-1R-expressing tumors can be localized. GLP-1R, located on beta cells, is overexpressed on insulinomas, which are insulin-secreting neuroendocrine tumors.",
  "synonyms": [
    "111In-DOTA-exendin-4",
    "[Lys40(Ahx-DOTA-111In)NH2]-exendin-4"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indium-in-111-dota-exendin-4/"
}