gallium Ga 68-NOTA-exendin-4

{
  "id": "MLC-T-ONC-013871",
  "term": "gallium Ga 68-NOTA-exendin-4",
  "field": "Oncology and biomedicine",
  "definition": "A radiopharmaceutical composed of the glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4 linked by the macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) to the positron-emitting radionuclide gallium Ga 68, with potential imaging activity upon positron emission tomography (PET)/computed tomography (CT). Upon administration of gallium Ga 68-NOTA-exendin-4, the exendin-4 moiety binds to GLP-1R. The radionuclide moiety can be detected using PET/CT and GLP-1R-expressing tumors can be localized. GLP-1R, located on beta cells, is overexpressed on insulinomas, which are insulin-secreting neuroendocrine tumors.",
  "synonyms": [
    "[68Ga]Ga-NOTA-exendin-4",
    "68Ga-NOTA-exendin-4"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-nota-exendin-4/"
}