Gallium Ga 68-NOTA-RM26

{
  "id": "MLC-T-ONC-013876",
  "term": "Gallium Ga 68-NOTA-RM26",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate containing RM26, a synthetic bombesin analogue and antagonist of the gastrin-releasing peptide receptor (GRPR), that is linked, through the macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) to the radionuclide gallium (Ga) 68, with potential use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68-NOTA-RM26, the peptide moiety targets and binds to GRPR. Upon PET/CT, GRPR-expressing tumor cells can then be visualized. GRPR, also called bombesin receptor subtype 2 (BB2), is a G protein-coupled seven-transmembrane receptor belonging to the bombesin receptor family. It is overexpressed in certain types of cancers.",
  "synonyms": [
    "68Ga-NOTA-RM26"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-nota-rm26/"
}