Gallium Ga 68-NOTA-Sgc8

{
  "id": "MLC-T-ONC-013877",
  "term": "Gallium Ga 68-NOTA-Sgc8",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of Sgc8, a 41 oligonucleotides long single-stranded DNA aptamer and protein tyrosine kinase-7 (PTK7; colon carcinoma kinase-4; CCK4)-targeting ligand, linked via the bi-functional agent 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA), to the beta-emitting radioisotope gallium Ga 68, with potential imaging activity during positron emission topography/computed tomography (PET/CT). Upon administration of gallium Ga 68-NOTA-Sgc8, the Sgc8 aptamer moiety targets and binds to PTK7 expressed on certain tumor cells. Upon PET/CT imaging, this radioconjugate can be used to detect and quantify PTK7-expressing tumor cells. PTK7, a member of the receptor tyrosine kinase (RTK) superfamily, is overexpressed in many different tumor cell types and plays an important role in tumor cell proliferation, migration and invasion.",
  "abbreviation": "68Ga-Sgc8",
  "synonyms": [
    "68Ga-labeled ssDNA aptamer Sgc8",
    "[68Ga]-Sgc8"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-nota-sgc8/"
}