gallium Ga 68-NOTA-hGZP

{
  "id": "MLC-T-ONC-013873",
  "term": "gallium Ga 68-NOTA-hGZP",
  "field": "Oncology and biomedicine",
  "definition": "A radiotracer composed of hGZP, a biotinylated human granzyme B peptide, conjugated with the bifunctional, macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) and labeled with the radionuclide gallium Ga 68, with potential imaging activity using positron emission tomography (PET). Upon administration, the hGZP moiety of gallium Ga 68-NOTA-hGZP targets and binds to granzyme B, a cytotoxic serine protease released by cytotoxic T lymphocytes (CTLs), in tumors. Upon PET imaging, tumoral granzyme B expression can be visualized, and CTL activation and activity can be assessed.",
  "synonyms": [
    "[68Ga]-NOTA-hGZP",
    "68Ga-NOTA-hGZP"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-nota-hgzp/"
}