gallium Ga 68-NOTA-anti-MMR-VHH2 nanobody

{
  "id": "MLC-T-ONC-013869",
  "term": "gallium Ga 68-NOTA-anti-MMR-VHH2 nanobody",
  "field": "Oncology and biomedicine",
  "definition": "A radiotracer composed of a nanobody against the macrophage mannose receptor (MMR, CD206) conjugated with the bifunctional, macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) and labeled with the radionuclide gallium Ga 68, with potential imaging activity using positron emission tomography (PET). Upon administration, the nanobody moiety of gallium Ga 68-NOTA-anti-MMR-VHH2 nanobody binds to MMR on tumor-associated macrophages (TAMs). Upon PET imaging, MMR-expressing TAMs can be visualized. MMR-expressing TAMs play a role in tumor growth and metastasis as well as immunotherapy resistance.",
  "synonyms": [
    "68GaNOTA-anti-MMR-VHH2",
    "68Ga-NOTA-MMR-VHH2 nanobody"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-nota-anti-mmr-vhh2-nanobody/"
}