gallium Ga 68-NOTA-anti-HER2 nanobody VHH1

{
  "id": "MLC-T-ONC-013868",
  "term": "gallium Ga 68-NOTA-anti-HER2 nanobody VHH1",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of a nanobody directed against human epidermal growth factor receptor 2 (HER2, EGFR2, ERBB2) that is linked, through the macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) to the radionuclide gallium (Ga) 68, with potential use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68-NOTA-anti-HER2 nanobody VHH1, the anti-HER2 antibody moiety targets and binds to HER2-expressing cells. This facilitates both detection of HER2-expressing tumor cells and assessment of responses to HER2-targeted chemotherapeutic agents during PET/CT. HER2, a tyrosine kinase is overexpressed on the cell surfaces of various tumor cell types.",
  "synonyms": [
    "68Ga-NOTA-anti-HER2 VHH1",
    "68Ga-HER2-nanobody VHH1",
    "68Ga-NOTA-2Rs15d",
    "gallium Ga 68-NOTA-anti-HER2-VHH1"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-nota-anti-her2-nanobody-vhh1/"
}