gallium Ga 68-NOTA-FAPI-04

{
  "id": "MLC-T-ONC-013872",
  "term": "gallium Ga 68-NOTA-FAPI-04",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of FAPI-04, a quinoline-based fibroblast activation protein (FAP)-targeted tracer belonging to the group of FAP inhibitors (FAPi), conjugated with the bifunctional, macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) and labeled with the radionuclide gallium Ga 68, with potential use as a tracer for FAP-expressing cancer-associated fibroblasts (CAFs) during positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68-NOTA-FAPI-04, the FAPI-04 moiety targets and binds to FAP-expressing CAFs. Upon binding, FAP-expressing cells can be detected during PET/CT imaging. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME).",
  "synonyms": [
    "68Ga-NOTA-FAPI04",
    "68Ga-NOTA-FAPI-04",
    "gallium Ga 68-NOTA-FAPI04"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-nota-fapi-04/"
}