gallium Ga 68/copper Cu 64-labeled FAPI-XT117

{
  "id": "MLC-T-ONC-013837",
  "term": "gallium Ga 68/copper Cu 64-labeled FAPI-XT117",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of FAPI-XT117, a fibroblast activation protein inhibitor (FAPi), labeled with the radionuclides gallium Ga 68 and copper Cu 64, with potential use as a tracer for FAP-expressing cancer-associated fibroblasts (CAFs) during positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68/copper Cu 64-labeled FAPI-XT117, the FAPI-XT117 moiety targets and binds to FAP-expressing CAFs. Upon binding, FAP-expressing cells can be detected during PET/CT imaging. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME).",
  "synonyms": [
    "68Ga/64Cu-FAPI-XT117"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-copper-cu-64-labeled-fapi-xt117/"
}