Gallium Ga 68-DOTA-FAPI-04

{
  "id": "MLC-T-ONC-013840",
  "term": "Gallium Ga 68-DOTA-FAPI-04",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of FAPI-04, a quinoline-based fibroblast activation protein (FAP)-targeted tracer belonging to the group of FAP inhibitors (FAPi), conjugated, through the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), to the radioisotope gallium Ga 68, with potential use as a tracer for FAP-expressing cancer-associated fibroblasts (CAFs) during positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68-DOTA-FAPI-04, the FAPI-04 moiety targets and binds to FAP-expressing CAFs. Upon binding, FAP-expressing cells can be detected during PET/CT imaging. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME).",
  "synonyms": [
    "68Ga-DOTA-FAPI-04",
    "68Ga-FAPi-04",
    "gallium-68-FAPi-04"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-dota-fapi-04/"
}