gallium Ga 68-DOTA-MGS5

{
  "id": "MLC-T-ONC-013841",
  "term": "gallium Ga 68-DOTA-MGS5",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of the minigastrin analog, MGS5, conjugated, via the bifunctional, macrocyclic chelating agent 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetra-acetic acid (DOTA), to the radioisotope gallium Ga 68, with potential use as a tracer for cholecystokinin receptor subtype 2 (CCK2R)-epressing tumor cells during positron emission tomography (PET)/computed tomography (CT). Upon intravenous administration, gallium Ga 68-DOTA-MGS5 targets and binds to tumor cells expressing CCK2R and these cells can be detected upon PET/CT imaging. CCK2R is expressed on a variety of tumor cell types, such as medullary thyroid carcinoma (MTC), and gastroenteropancreatic and bronchopulmonary neuroendocrine tumors (NETs).",
  "synonyms": [
    "68Ga-DOTA-MGS5",
    "68Ga-DOTA-minigastrin analog MGS5",
    "68Ga-labeled minigastrin analogue MGS5"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-dota-mgs5/"
}