Gallium Ga 68 FAP-2286

{
  "id": "MLC-T-ONC-013822",
  "term": "Gallium Ga 68 FAP-2286",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of FAP-2286, a fibroblast activation protein (FAP)-targeted peptide, attached to a linker and tetraazacyclododecane tetraacetic acid chelator, conjugated to the radioisotope gallium Ga 68, with potential use as a tracer for FAP-expressing cancer-associated fibroblasts (CAFs) during positron emission tomography (PET). Upon administration of gallium Ga 68 FAP-2286, the FAP-2286 moiety targets and binds to FAP-expressing CAFs. Upon binding, FAP-expressing cells can be detected during PET imaging. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME).",
  "synonyms": [
    "68Ga-FAP-2286",
    "gallium-68-FAP-2286",
    "gallium-68 labelled FAP-2286"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-fap-2286/"
}