gallium Ga 68 EB-ss-CPT

{
  "id": "MLC-T-ONC-013821",
  "term": "gallium Ga 68 EB-ss-CPT",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of the amphiphilic camptothecin (CPT) prodrug EB-ss-CPT, labeled with the radioisotope gallium Ga 68, with potential use as a tracer for tumor cells during positron emission tomography (PET). EB-ss-CPT is composed of CPT conjugated, via a redox-responsive disulfide linker, to an albumin-binding Evans blue (EB) derivative. Upon administration of gallium Ga 68 EB-ss-CPT, the EB-ss-CPT moiety binds to endogenous albumin and the resulting albumin-bound nanocomplex accumulates in tumor cells. This allows the detection and visualization of tumor cells upon PET imaging.",
  "synonyms": [
    "68Ga-EB-ss-CPT",
    "68Ga-EB-CPT",
    "gallium Ga 68-labeled CPT-ss-EB"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-eb-ss-cpt/"
}