Gallium Ga 68-THP-PSMA

{
  "id": "MLC-T-ONC-013887",
  "term": "Gallium Ga 68-THP-PSMA",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of a human prostate specific membrane antigen (PSMA)-targeting agent conjugated, via the tris(hydroxypyridinone) (THP) chelator, to the radioisotope gallium Ga 68, with potential use as a tracer for PSMA-expressing tumors during positron emission tomography (PET). Upon intravenous administration of the gallium Ga 68-THP-PSMA, the PSMA moiety targets and binds to PSMA-expressing tumor cells. Upon PET imaging, PSMA-expressing tumor cells can be detected. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells.",
  "abbreviation": "68Ga-THP-PSMA",
  "synonyms": [
    "gallium Ga 68-tris(hydroxypyridinone)-prostate-specific membrane antigen",
    "gallium Ga 68-labeled THP-PSMA"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-thp-psma/"
}