Gallium Ga 68-PSMA-617

{
  "id": "MLC-T-ONC-013883",
  "term": "Gallium Ga 68-PSMA-617",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of PSMA-617, a human prostate-specific membrane antigen (PSMA)-targeting ligand, conjugated to the radioisotope gallium Ga 68, with potential use as a tracer for PSMA-expressing tumors during positron emission tomography (PET)/computed tomography (CT). Upon intravenous administration of 68Ga-PSMA-617, the PSMA-617 moiety targets and binds to PSMA-expressing tumor cells. Upon binding, PSMA-expressing tumor cells can be detected during PET/CT imaging. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells.",
  "synonyms": [
    "68Ga-PSMA-617",
    "gallium-68 PSMA-617"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-psma-617/"
}