Gallium Ga 68-RGD

{
  "id": "MLC-T-ONC-013886",
  "term": "Gallium Ga 68-RGD",
  "field": "Oncology and biomedicine",
  "definition": "A radiopharmaceutical agent comprised of a cyclic arginine-glycine-aspartic acid (Arg-Gly-Asp/RGD) peptide labeled with gallium Ga 68, with potential alphaVbeta3 integrin (avb3) imaging activity during positron emission topography (PET). After intravenous administration, gallium Ga 68-RGD selectively binds to avb3 on the cell membrane via the cyclic RGD motif. Upon PET imaging, avb3-expressing tumor cells can be visualized and their expression levels can be quantified. avb3, a member of the integrin receptor family, is overexpressed on certain tumor cells and tumor endothelial cells while minimally or not expressed on healthy, normal cells; it plays a key role in angiogenesis, tumor proliferation and survival.",
  "synonyms": [
    "(68)Ga-RGD",
    "RGD (68Ga)"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-rgd/"
}