2-fluoropropionyl-labeled pegylated dimeric RGD peptide

{
  "id": "MLC-T-ONC-009527",
  "term": "2-fluoropropionyl-labeled pegylated dimeric RGD peptide",
  "field": "Oncology and biomedicine",
  "definition": "A radiopharmaceutical agent comprised of a pegylated dimeric arginine-glycine-aspartic acid (RGD)-based peptide labeled with 2-fluoropropionyl, with potential alphaVbeta3 integrin imaging activity upon positron emission topography (PET). The RGD moiety of 2-fluoropropionyl-labeled pegylated dimeric RGD peptide targets and binds to alphaVbeta3 integrin. Upon PET imaging, alphaVbeta3 integrin-expressing tumor cells can be visualized and expression levels can be quantified. Compared to other fluorine F 18 labeled RGD-containing peptides, this agent shows increased affinity to alphaVbeta3 integrin, enhanced tumor uptake as well as improved pharmacokinetics. alphaVbeta3 integrin, overexpressed on certain tumor cells and tumor endothelial cells, plays a key role in angiogenesis, tumor proliferation and survival.",
  "abbreviation": "[18F] FPPRGD2",
  "synonyms": [
    "fluorine 18 ((18)F) FPPRGD2"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/2-fluoropropionyl-labeled-pegylated-dimeric-rgd-peptide/"
}