2G-1 TCR Retroviral Vector-Transduced Lymphocytes

{
  "id": "MLC-T-ONC-009528",
  "term": "2G-1 TCR Retroviral Vector-Transduced Lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous human T-lymphocytes isolated from renal cell cancer (RCC) patient and transduced with 2G-1 TCR, a retroviral vector encoding the alpha and beta chains of a T-cell receptor that recognizes TNF-related apoptosis inducing ligand (TRAIL) bound to death receptor 4 (DR4), with potential immunostimulating and antineoplastic activities. After transduction, expansion in culture, and introduction into the RCC patient, 2G-1 TCR retroviral vector-transduced lymphocytes may stimulate a cytotoxic T lymphocyte (CTL) response against RCC cells with TRAIL bound to DR4 on their surfaces. TRAIL, a member of the TNF superfamily, is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of tumor cells when bound to its receptors; DR4 (TRAIL receptor 1), a member of the TNF receptor family, is overexpressed by a variety of malignant cell types.",
  "synonyms": [
    "PG13-A(F/K)-F-SGSG-T2a-B(opt)(2G-1 TCR) retroviral vector-transduced lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/2g-1-tcr-retroviral-vector-transduced-lymphocytes/"
}