anti-hCD70-CAR retroviral vector-transduced autologous PBLs

{
  "id": "MLC-T-ONC-010729",
  "term": "anti-hCD70-CAR retroviral vector-transduced autologous PBLs",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding for a T-cell chimeric antigen receptor (CAR) gene specific for the human cluster of differentiation 70 (CD70), with potential immunostimulatory and antineoplastic activities. Autologous PBLs from a patient with CD70-positive cancer are transduced with a retroviral vector that encodes the CAR gene specific for CD70. After expansion in culture and reintroduction into the patient, anti-hCD70-CAR retroviral vector-transduced autologous PBLs bind to the CD70 antigen on tumor cell surfaces; subsequently, CD70-expressing tumor cells are lysed. CD70, the ligand for the costimulatory receptor CD27, is overexpressed on the surfaces of various cancer cell types.",
  "synonyms": [
    "anti-hCD70 CAR autologous PBLs",
    "anti-hCD70 autologous CAR-transduced T cells",
    "anti-hCD70-CAR retroviral vector-transduced autologous peripheral blood lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-hcd70-car-retroviral-vector-transduced-autologous-pbls/"
}