autologous PBLs retrovirally-transduced with TCRs targeting neoantigens

{
  "id": "MLC-T-ONC-011736",
  "term": "autologous PBLs retrovirally-transduced with TCRs targeting neoantigens",
  "field": "Oncology and biomedicine",
  "definition": "Autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding T-cell receptors (TCRs) specific for a patient's individual and unique mutated antigens, with potential immunostimulating and antineoplastic activities. Tumor cells are analyzed to identify and isolate specific mutated tumor-associated antigens (TAAs) that are expressed by the patient's tumor cells; then T-cell receptor coding sequences are engineered to target the patient's TAAs and inserted into retroviral vectors. After transduction, expansion in culture, and reintroduction into the patient, neoantigen-specific TCRs retroviral vector-transduced autologous PBLs recognize and bind to tumor cells expressing the patient's neoantigens, which results in a specific cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells.",
  "synonyms": [
    "neoantigen-reactive TCRs-transduced autologous PBLs",
    "autologous PBLs expressing mutated neoantigen-specific T-cell receptors",
    "neoantigen-specific TCRs gene-transduced autologous PBLs",
    "individual patient TCR-transduced autologous PBLs",
    "autologous peripheral blood lymphocytes retrovirally-transduced with TCRs targeting neoantigens"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-pbls-retrovirally-transduced-with-tcrs-targeting-neoantigens/"
}