NY-ESO-1 reactive TCR retroviral vector transduced autologous PBL

{
  "id": "MLC-T-ONC-015566",
  "term": "NY-ESO-1 reactive TCR retroviral vector transduced autologous PBL",
  "field": "Oncology and biomedicine",
  "definition": "Human autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NY-ESO-1 reactive TCR-transduced autologous PBLs bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types; the TCR is specific for NY-ESO-1:157-165.",
  "synonyms": [
    "anti-NY-ESO-1 TCR retroviral vector-transduced lymphocytes",
    "anti-NY-ESO-1 TCR gene-engineered lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ny-eso-1-reactive-tcr-retroviral-vector-transduced-autologous-pbl/"
}