anti-HLA-A2/NY-ESO-1 TCR-transduced autologous T lymphocytes

{
  "id": "MLC-T-ONC-010791",
  "term": "anti-HLA-A2/NY-ESO-1 TCR-transduced autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous human peripheral blood T lymphocytes transduced with a lentiviral or retroviral vector encoding a human leukocyte antigen A2 (HLA-A2)-restricted anti-cancer-testis antigen 1 (NY-ESO-1) T-cell receptor (TCR) gene, with potential antineoplastic activity. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and re-introduction into the patient, the anti-HLA-A2/NY-ESO-1 TCR-transduced autologous T lymphocytes recognize and bind to NY-ESO-1/HLA-A2-positive tumor cells. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types.",
  "synonyms": [
    "autologous HLA-A2/NY-ESO-1-specific TCR gene-transduced T lymphocytes",
    "autologous anti-HLA-A2/NY-ESO1 TCR-transduced T lymphocytes",
    "anti-HLA-A2/NY-ESO1 TCR-transduced autologous T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-hla-a2-ny-eso-1-tcr-transduced-autologous-t-lymphocytes/"
}