Anti-HLA-A2-MAGE-A4/Anti-CD3 Bispecific Antibody RO7444973

{
  "id": "MLC-T-ONC-010790",
  "term": "Anti-HLA-A2-MAGE-A4/Anti-CD3 Bispecific Antibody RO7444973",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific T-cell engaging antibody directed against both the tumor-associated antigen (TAA) human leukocyte antigen (HLA)-A2-restricted, melanoma-associated antigen A4 (MAGE-A4) and T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-HLA-A2-MAGE-A4/Anti-CD3 bispecific antibody RO7444973 simultaneously binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and HLA-A2 MAGE-A4 on MAGE-A4-expressing tumor cells. This activates and redirects CTLs to MAGE-A4-expressing tumor cells, which results in the CTL-mediated cell death of MAGE-A4-expressing tumor cells. MAGE-A4 is overexpressed by a variety of cancer cell types.",
  "synonyms": [
    "anti-HLA-A2-MAGE-A4/anti-CD3 bispecific antibody RG6129",
    "anti-HLA-A2-MAGE-A4/CD3 bispecific antibody RO7444973",
    "HLA-A2-MAGE-A4 x CD3 bispecific antibody RO7444973"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-hla-a2-mage-a4-anti-cd3-bispecific-antibody-ro7444973/"
}