MAGE-A4-specific TCR gene-transduced T lymphocytes TBI-1201

{
  "id": "MLC-T-ONC-014973",
  "term": "MAGE-A4-specific TCR gene-transduced T lymphocytes TBI-1201",
  "field": "Oncology and biomedicine",
  "definition": "Autologous human T lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4), with potential immunostimulatory and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, MAGE-A4-specific TCR gene-transduced T lymphocytes TBI-1201 binds to tumor cells expressing MAGE-A4. This may result in both an inhibition of growth and increased cell death for MAGE-A4-expressing tumor cells. The tumor-associated antigen MAGE-A4 is overexpressed by a variety of cancer cell types.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mage-a4-specific-tcr-gene-transduced-t-lymphocytes-tbi-1201/"
}