HLA-DP0401/0402-restricted, MAGE-A3-reactive T cell receptor-transduced autologous T cells

{
  "id": "MLC-T-ONC-014153",
  "term": "HLA-DP0401/0402-restricted, MAGE-A3-reactive T cell receptor-transduced autologous T cells",
  "field": "Oncology and biomedicine",
  "definition": "Human autologous T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-DP0401/0402-restricted, melanoma antigen A3 (MAGE-A3), with potential antineoplastic activity. CD4-positive cells are isolated from a patient, transduced with an anti-MAGE-A3-DP0401/0402 restricted TCR, expanded ex vivo, and reintroduced into the HLA-DP0401/0402 positive patient. Then, the HLA-DP0401/0402-restricted, MAGE-A3-reactive TCR-transduced autologous T cells bind to tumor cells expressing the MAGE-A3 antigen, which may result in both an inhibition of growth and increased cell death for MAGE-A3-expressing cancer cells. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer cell types.",
  "synonyms": [
    "anti-MAGE-A3-DP4 TCR PBL"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hla-dp0401-0402-restricted-mage-a3-reactive-t-cell-receptor-transduced-t-cells/"
}