HLA-A2-restricted synthetic glioma antigen peptides vaccine

{
  "id": "MLC-T-ONC-014152",
  "term": "HLA-A2-restricted synthetic glioma antigen peptides vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A synthetic peptide cancer vaccine consisting of HLA-A2-restricted peptides derived from glioma-associated antigens (GAA) with potential immunostimulating and antineoplastic activities. Upon administration, HLA-A2-restricted synthetic glioma antigen peptides vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing the corresponding GAAs, resulting in glioma tumor cell lysis. HLA-A2 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A2 may improve antigenic peptide immunogenicity.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hla-a2-restricted-synthetic-glioma-antigen-peptides-vaccine/"
}