MAGE-A3-expressing adenovirus type5 vaccine

{
  "id": "MLC-T-ONC-014970",
  "term": "MAGE-A3-expressing adenovirus type5 vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An oncolytic adenoviral vaccine composed of a replication-defective, E1- and E3-deleted adenovirus serotype 5 (Ad5) with a transgene encoding the human melanoma antigen A3 (MAGE-A3), with potential antineoplastic activity. Upon administration, MAGE-A3-expressing adenovirus type 5 vaccine selectively replicates in cancer cells and expresses MAGE-A3. This induces an immune response against tumor cells expressing the MAGE-A3 antigen, which leads to tumor cell death. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer cell types.",
  "abbreviation": "Ad-MAGE-A3",
  "synonyms": [
    "adenovirus/MAGE-A3"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mage-a3-expressing-adenovirus-type5-vaccine/"
}