MAGE-A3/12-specific TCR gene-transduced autologous PBLs

{
  "id": "MLC-T-ONC-014969",
  "term": "MAGE-A3/12-specific TCR gene-transduced autologous PBLs",
  "field": "Oncology and biomedicine",
  "definition": "Human autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T-cell receptor (TCR) that recognizes the human melanoma antigens A3 and A12 (MAGE-A3/12), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the MAGE-A3/12-specific TCR gene-transduced autologous PBLs bind to and lyse tumor cells expressing MAGE-A3/12, which may halt the growth of MAGE-A3/12-expressing cancer cells. MAGE-A3 and MAGE-A12, tumor associated antigens and members of the melanoma-associated antigen gene family, are overexpressed by a variety of cancer cell types.",
  "synonyms": [
    "anti-MAGE A3/12 TCR PBLs",
    "MAGE-A3/12-specific T-cell receptor gene-transduced autologous peripheral blood lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mage-a3-12-specific-tcr-gene-transduced-autologous-pbls/"
}