MAGE-A3 reactive T cell receptor-transduced autologous T cells

{
  "id": "MLC-T-ONC-014968",
  "term": "MAGE-A3 reactive T cell receptor-transduced autologous T cells",
  "field": "Oncology and biomedicine",
  "definition": "Human autologous T-lymphocytes transduced with a retroviral vector encoding a T cell receptor (TCR) specific for the human melanoma antigen A3 (MAGE-A3), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the MAGE-A3 reactive TCR-transduced autologous T cells bind to tumor cells expressing MAGE-A3, which may halt the growth of MAGE-A3-expressing cancer cells; the TCR is specific for MAGE-A3:168-176.",
  "synonyms": [
    "MAGE-A3 T cell receptor-transduced autologous T cells",
    "MAGE-A3 TCR-transduced autologous T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mage-a3-reactive-t-cell-receptor-transduced-autologous-t-cells/"
}