astuprotimut-R

{
  "id": "MLC-T-ONC-011265",
  "term": "astuprotimut-R",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of a recombinant form of human melanoma antigen A3 (MAGE-A3) combined with a proprietary adjuvant with potential immunostimulatory and antineoplastic activities. Upon administration, astuprotimut-R may stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells expressing the MAGE-A3 antigen, resulting in tumor cell death. MAGE-A3, a tumor-associated antigen (TAA) originally discovered in melanoma cells, is expressed by various tumor types. The proprietary immunostimulating adjuvant in this agent is composed of a specific combination of immunostimulating compounds selected to increase the anti-tumor immune response to MAGE-A3.",
  "synonyms": [
    "immunotherapeutic GSK1572932A",
    "recombinant MAGE-A3 ASCI GSK1203486A"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/astuprotimut-r/"
}