genetically-modified MAGE-A3-expressing MG1 Maraba virus vaccine

{
  "id": "MLC-T-ONC-013932",
  "term": "genetically-modified MAGE-A3-expressing MG1 Maraba virus vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A vaccine consisting of the attenuated, genetically-modified, oncolytic form of the Maraba virus, MG1, which has been engineered to express a gene encoding the cancer testis antigen melanoma antigen family A3 (MAGE-A3), with potential antineoplastic activity. Upon administration of genetically-modified MAGE-A3-expressing MG1 Maraba virus vaccine, the attenuated Maraba virus selectively and rapidly replicates in cancer cells; however, it is unable to replicate in normal, healthy cells. This induces a selective Maraba virus-mediated cytotoxicity in those cancer cells, and leads to cancer cell lysis. In addition, the expression of MAGE-A3 further stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing MAGE-A3. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer cell types. The attenuated virus is a double mutant strain with single amino acid substitutions occurring in both G protein (Q242R) and M protein (L123W).",
  "synonyms": [
    "MG1MA3",
    "MG1 Maraba/MAGE-A3"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/genetically-modified-mage-a3-expressing-mg1-maraba-virus-vaccine/"
}