MAGE-A1-specific T-cell receptor-transduced autologous T cells

{
  "id": "MLC-T-ONC-014967",
  "term": "MAGE-A1-specific T-cell receptor-transduced autologous T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous CD4- and CD8-positive T lymphocytes genetically modified to express a T-cell receptor (TCR) that specifically targets the human melanoma-associated antigen A1 (MAGE-A1), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the MAGE-A1-specific TCR-transduced autologous T cells bind to tumor cells expressing MAGE-A1, which may halt the growth of and kill MAGE-A1-expressing cancer cells. MAGE-A1 is a tumor-associated antigen (TAA) overexpressed by a variety of cancer cell types.",
  "synonyms": [
    "MAGE-A1-specific T-cell receptor-transduced autologous CD8+ and CD4+ T cells",
    "MAGE-A1-specific TCR-transduced autologous T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mage-a1-specific-t-cell-receptor-transduced-autologous-t-cells/"
}