autologous anti-MAGE-A1 TCR-engineered T cells TSC-204-C0702

{
  "id": "MLC-T-ONC-011468",
  "term": "autologous anti-MAGE-A1 TCR-engineered T cells TSC-204-C0702",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that are engineered to express a T-cell receptor (TCR) specific for melanoma-associated antigen A1 (MAGE-A1) presented on human leukocyte antigen (HLA)-C*07:02, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-MAGE-A1 TCR-engineered T cells TSC-204-C0702 specifically recognize and bind to MAGE-A1 expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing MAGE-A1. MAGE-A1 is a tumor-associated antigen (TAA) overexpressed by a variety of cancer cell types.",
  "synonyms": [
    "autologous MAGE-A1-specific HLA-C07:02-restricted TCR-expressing T lymphocytes TSC-204-C0702",
    "MAGE-A1-specific HLA-C07:02-restricted TCR-engineered T cells TSC-204-C0702",
    "MAGE-A1-specific TCR-transduced autologous T cells TSC-204-C0702",
    "MAGE-A1-specific TCR transduced autologous T cells TSC-204-C0702",
    "T-cell receptor engineered T Cells TSC-204-C0702"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-mage-a1-tcr-engineered-t-cells-tsc-204-c0702/"
}