autologous TCR-engineered T cells IMA202

{
  "id": "MLC-T-ONC-011771",
  "term": "autologous TCR-engineered T cells IMA202",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) targeting patient-specific tumor associated antigens (TAAs), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous TCR-engineered T cells IMA202 specifically recognize and bind to the TAA on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the TAA-positive cancer cells.",
  "synonyms": [
    "IMA202 T-cell product",
    "IMA202 T cells",
    "ACTengine IMA202"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-tcr-engineered-t-cells-ima202/"
}