PRAME-targeting TCR-engineered NK cells

{
  "id": "MLC-T-ONC-016204",
  "term": "PRAME-targeting TCR-engineered NK cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of natural killer (NK) cells that are engineered to express a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME), with potential antineoplastic activity. Upon administration, the PRAME-targeting TCR-engineered NK cells specifically recognize and bind to PRAME expressed on cancer cells, thereby lysing the PRAME-expressing cancer cells. PRAME is overexpressed by a variety of cancer cell types.",
  "synonyms": [
    "engineered PRAME-TCR NKs",
    "PRAME-targeted TCR NK cells",
    "PRAME-TCR-NK cells",
    "PRAME-TCR-NKs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/prame-targeting-tcr-engineered-nk-cells/"
}