TCR-engineered T cells HRYZ-T101

{
  "id": "MLC-T-ONC-017001",
  "term": "TCR-engineered T cells HRYZ-T101",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of genetically engineered T lymphocytes expressing a T-cell receptor (TCR) targeting a specific tumor-associated antigen (TAA) of the human papillomavirus (HPV) type 18 (HPV-18), with potential antineoplastic activity. Upon administration, HPV-18 expressing TCR T cells target and bind to tumor cells expressing the HPV-18 TAA leading to selective cytotoxicity in HPV-18 TAA-expressing tumor cells. HPV18 TAAs are overexpressed in a variety of tumor cell types.",
  "synonyms": [
    "TCR-T cells HRYZ-T101"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tcr-engineered-t-cells-hryz-t101/"
}