Autologous E6 T cell receptor genetically-modified T cells

{
  "id": "MLC-T-ONC-011612",
  "term": "Autologous E6 T cell receptor genetically-modified T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of human autologous peripheral blood lymphocytes (PBLs) that have been genetically engineered to express a T-cell receptor (TCR) that specifically targets the viral oncoprotein human papillomavirus type 16 (HPV-16) E6, with potential antineoplastic activity. Upon administration, the HPV E6 TCR genetically-modified T cells target and bind to HPV-16 E6-expressing tumor cells, which leads to specific cytotoxic T-lymphocyte (CTL)-mediated killing of HPV-16 E6-positive tumor cells. HPV-16 E6, a cell surface glycoprotein, plays a key role in the tumorigenesis of various HPV-associated tumors and is absent from healthy human tissues.",
  "synonyms": [
    "autologous E6 TCR T cells",
    "autologous anti-HPV-16 E6 TCR T cells",
    "autologous HPV-16 E6 TCR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-e6-t-cell-receptor-genetically-modified-t-cells/"
}