Autologous dnTGF-BRII-armored anti-STEAP2 CAR T cells AZD0754

{
  "id": "MLC-T-ONC-011611",
  "term": "Autologous dnTGF-BRII-armored anti-STEAP2 CAR T cells AZD0754",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the metalloreductase six-transmembrane epithelial antigen of prostate-2 (STEAP2; STAMP1) and the dominant negative (dn) form of transforming growth factor-beta (TGF-beta; TGFb) receptor 2 (dnTGF-BRII; dnTGFbR2), with potential immunomodulating and antineoplastic activities. Upon reintroduction into the patient, autologous dnTGF-BRII-armored anti-STEAP2 CAR T cells AZD0754 are directed to and induce selective toxicity in STEAP2-expressing tumor cells. STEAP2 is a cell surface antigen overexpressed in prostate cancer with limited expression in normal tissue. The inclusion of dnTGF-BRII blocks the signaling of the immunosuppressive cytokine TGFb in the tumor microenvironment (TME) and makes the AZD0754 CAR T cells resistant to TGFb. TGFb negatively regulates T-cell proliferation and activation and plays a key role in tumor immune suppression.",
  "synonyms": [
    "autologous anti-STEAP2 CAR T cells AZD0754",
    "autologous dnTGF-BRII-armored STEAP2-targeted CAR-T cells AZD0754"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-dntgf-brii-armored-anti-steap2-car-t-cells-azd0754/"
}