gorilla-derived adenovirus-expressing HPV-16/18 E6/E7 vaccine

{
  "id": "MLC-T-ONC-014008",
  "term": "gorilla-derived adenovirus-expressing HPV-16/18 E6/E7 vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An off-the-shelf (OTS) cancer vaccine comprised of a genetically engineered, replication-deficient gorilla-derived adenovirus encoding human papillomavirus (HPV) types 16 and 18 E6/E7 antigens, with potential immunostimulating and antineoplastic activities. Upon administration of gorilla-derived adenovirus expressing HPV-16/18 E6/E7 vaccine PRGN-2009, the adenovirus infects and expresses the HPV-16/18 E6/E7 proteins. The expressed proteins stimulate the host immune system to produce antigen-specific neutralizing antibodies and to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing HPV-16/18 E6/E7 antigens, thereby inducing tumor cell lysis. HPV oncoproteins play a key role in the development of cervical intraepithelial neoplasia (CIN) and cervical carcinoma.",
  "synonyms": [
    "HPV vaccine PRGN-2009"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gorilla-derived-adenovirus-expressing-hpv-16-18-e6-e7-vaccine/"
}